The major histocompatibility complex (MHC) plays a crucial role in the immune response to infectious diseases. The aim of the present study was to investigate the structural and functional characteristics and possible duplication of the MHC-DQA genes in the Chinese yakow, which is well adapted to the Qinghai–Tibetan Plateau. Two full-length cDNA sequences and partial 5’- and 3’-untranslated regions (UTRs) were retrieved and denoted as Bogr×BoLA-DQA*0101 (DQA1) and Bogr×BoLA-DQA*2001 (DQA2), respectively. The percentage of nucleotide and amino acid sequences homology between Bogr×BoLA-DQA1 and Bogr×BoLA-DQA2 showed that these two sequences have more identity to alleles of the corresponding DQA1 and DQA2 genes from other counterparts than to each other. Moreover, the Bogr×BoLA-DQA1 and -DQA2 exhibited considerable variation with 99 nucleotide polymorphisms along the length of the coding regions, leading to 52 amino acid polymorphisms. The phylogenetic tree investigation also demonstrated that there is a larger genetic gap within these two identified genes than within orthologous genes from different animals, suggesting that these sequences belong to nonallelic and duplicated types in the Chinese yakow. This is the first report to isolate and identify the MHC-DQA1 and -DQA2 genes. This result will deepen our understanding of MHC diversity among different ruminant species based on comparative population genetics.
CIFOR-ICRAF s’attaque aux défis et aux opportunités locales tout en apportant des solutions aux problèmes mondiaux concernant les forêts, les paysages, les populations et la planète.
Nous fournissons des preuves et des solutions concrètes pour transformer l’utilisation des terres et la production alimentaire : conserver et restaurer les écosystèmes, répondre aux crises mondiales du climat, de la malnutrition, de la biodiversité et de la désertification. En bref, nous améliorons la vie des populations.
Explore eventos futuros e passados em todo o mundo e online, sejam hospedados pelo CIFOR-ICRAF ou com a participação de nossos pesquisadores.
Découvrez les évènements passés et à venir dans le monde entier et en ligne, qu’ils soient organisés par le CIFOR-ICRAF ou auxquels participent nos chercheurs.
Jelajahi acara-acara mendatang dan yang telah lalu di lintas global dan daring, baik itu diselenggarakan oleh CIFOR-ICRAF atau dihadiri para peneliti kami.
Explore eventos futuros y pasados organizados por CIFOR-ICRAF o con la participación de nuestros investigadores.
CIFOR-ICRAF publie chaque année plus de 750 publications sur l’agroforesterie, les forêts et le changement climatique, la restauration des paysages, les droits, la politique forestière et bien d’autres sujets encore, et ce dans plusieurs langues. .
CIFOR-ICRAF a un impact fondé sur la science. Nous menons des recherches innovantes, renforçons les capacités de nos partenaires et engageons activement le dialogue avec toutes les parties prenantes, en apportant les dernières connaissances sur les forêts, les arbres, les paysages et les populations à la prise de décision au niveau mondial.
CIFOR-ICRAF s’attaque aux défis et aux opportunités locales tout en apportant des solutions aux problèmes mondiaux concernant les forêts, les paysages, les populations et la planète.
Nous fournissons des preuves et des solutions concrètes pour transformer l’utilisation des terres et la production alimentaire : conserver et restaurer les écosystèmes, répondre aux crises mondiales du climat, de la malnutrition, de la biodiversité et de la désertification. En bref, nous améliorons la vie des populations.
CIFOR–ICRAF achieves science-driven impact. We conduct innovative research, strengthen partners’ capacity and actively engage in dialogue with all stakeholders, bringing the latest insights on forests, trees, landscapes and people to global decision making.
CIFOR–ICRAF publishes over 750 publications every year on agroforestry, forests and climate change, landscape restoration, rights, forest policy and much more – in multiple languages.
CIFOR–ICRAF addresses local challenges and opportunities while providing solutions to global problems for forests, landscapes, people and the planet.
We deliver actionable evidence and solutions to transform how land is used and how food is produced: conserving and restoring ecosystems, responding to the global climate, malnutrition, biodiversity and desertification crises. In short, improving people’s lives.
